Endocrine Abstracts

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency is the most common disorder, in which lack of the enzyme causes deficiency aldosterone and cortisol. The result of this deficiency is an increased level of ACTH. The classic form appears in early childhood and may be associated with the development of abnormal genitalia. Clinically older patients present the GnRH-independent precocious puberty with rapid growth and advanced bone age. We present the case of 9-year-...

Leptin, adiponectin and resistin play an essential role in regulation of body mass, which is controlled by thyroid hormones levels.The aim of the study was to evaluate leptin, adiponectin and resistin levels in young patients with Graves’ disease and in children with Hashimoto’s thyroiditis.The study group formed 78 patients suffering from Graves’ disease (30 girls and 2 boys; aged from 6 to 21- mean 15.2 years) and ...

The risk of malignancy in thyroid nodules correlates with the presence of ultrasound features. In adults, ultrasound risk-classification systems have been proposed to indicate the need for further invasive diagnosis. Furthermore, elastography has been shown to support differential diagnosis of thyroid nodules. The purpose of our study was to assess the application of the American Thyroid Association (ATA) and British Thyroid Association (BTA) ultrasound risk-classification sys...

Introduction: Bloom syndrome (BS) is a rare autosomal recessive disorder caused by mutations in the BLM gene. Classic dysmorphic features include a long, narrow face, micrognathism and prominent nose and ears. Other features of the disease include pre- and post-natal growth failure, skin rash following sun exposure, hyper-pigmented areas or cafe-au-lait lesions, high-pitched voice and immunodeficiency. The most serious complication of BS is the significant increase in...

Introduction: Hashimoto’s thyroiditis (HT) is the most frequent cause of thyroid disfunction in children and its incidence is increasing. Although thyroid cancer is an uncommon childhood malignancy with a reported incidence of about 0.59 cases per 100,000, there are data suggesting the comorbidity of papillary thyroid carcinoma with autoimmune thyroiditis (AIT) in children. Ultrasound elastography is a non-invasive imaging, based on estimation of mechanical properties (el...

Thyroid disease let to change of weight – in hyperthyroid body mass is reduced, but in hypothyroid it is increased. Recently researches suggest that many new bioactive substances, like ghrelin and obestatin, play a role in regulation of body mass. These closely related hormones have paradoxically different effects- ghrelin increases, but obestatin decreases appetite. The aim of the study was to evaluate ghrelin and obestatin levels in young patients with untreated Graves&...